Drug interactions
Pravastatin + Sotorasib
Severity: Minor
Pravastatin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib may inhibit P-gp, which could modestly increase exposure to P-gp substrates. Pravastatin is only a minor P-gp substrate, so the effect is likely small.
What this interaction means in plain words
Pravastatin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by sotorasib increases pravastatin absorption.
What to do
No dose change usually needed; monitor for muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Pravastatin with Sotorasib?
MediHelp rates the interaction as minor. Pravastatin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib may inhibit P-gp, which could modestly increase exposure to P-gp substrates. Pravastatin is only a minor P-gp substrate, so the effect is likely small.
How serious is the interaction between Pravastatin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change usually needed; monitor for muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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