Drug interactions
Pravastatin + Voclosporin
Severity: Moderate
Pravastatin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin may increase pravastatin concentrations, raising the possibility of statin-related muscle toxicity. Magnitude in practice is uncertain.
What this interaction means in plain words
Pravastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pravastatin belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Voclosporin inhibits OATP1B1, which mediates hepatic uptake of pravastatin.
What to do
Use the lowest effective pravastatin dose and monitor for myalgia or weakness. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Pravastatin with Voclosporin?
MediHelp rates the interaction as moderate. Pravastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin may increase pravastatin concentrations, raising the possibility of statin-related muscle toxicity. Magnitude in practice is uncertain.
How serious is the interaction between Pravastatin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pravastatin dose and monitor for myalgia or weakness. Check CK if symptoms develop.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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