Drug interactions
Praziquantel + Repotrectinib
Severity: Moderate
Praziquantel and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer and may substantially lower praziquantel concentrations. This could cause treatment failure.
What this interaction means in plain words
Praziquantel and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Praziquantel belongs to Anti Parasitic; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4, increasing presystemic and hepatic clearance of praziquantel.
What to do
Monitor for lack of efficacy and arrange follow-up testing. Delay praziquantel if oncology treatment can be paused, or consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Praziquantel with Repotrectinib?
MediHelp rates the interaction as moderate. Praziquantel and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is a CYP3A4 inducer and may substantially lower praziquantel concentrations. This could cause treatment failure.
How serious is the interaction between Praziquantel and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lack of efficacy and arrange follow-up testing. Delay praziquantel if oncology treatment can be paused, or consider alternatives.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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