Drug interactions
Praziquantel + Stiripentol
Severity: Moderate
Praziquantel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4, so praziquantel exposure may change unpredictably. Reduced levels could compromise antiparasitic efficacy, while increased levels may worsen dose-related adverse effects.
What this interaction means in plain words
Praziquantel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Praziquantel belongs to Anti Parasitic; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects that alter praziquantel metabolism.
What to do
Monitor clinical response and tolerability of praziquantel, and confirm treatment success in the infection being treated. Consider a dose adjustment or alternative if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Praziquantel and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Praziquantel with Stiripentol?
MediHelp rates the interaction as moderate. Praziquantel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4, so praziquantel exposure may change unpredictably. Reduced levels could compromise antiparasitic efficacy, while increased levels may worsen dose-related adverse effects.
How serious is the interaction between Praziquantel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability of praziquantel, and confirm treatment success in the infection being treated. Consider a dose adjustment or alternative if efficacy appears reduced.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
