Drug interactions
Prednisone + Rosiglitazone
Severity: Moderate
Prednisone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone can cause hyperglycemia and may reduce the glucose-lowering effect of rosiglitazone. Control of diabetes may worsen during steroid courses.
What this interaction means in plain words
Prednisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Glucocorticoids promote gluconeogenesis and insulin resistance, opposing the insulin-sensitising action of rosiglitazone.
What to do
Increase blood glucose monitoring while on prednisone and adjust antidiabetic therapy as needed. Reduce doses again as the steroid is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Prednisone with Rosiglitazone?
MediHelp rates the interaction as moderate. Prednisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone can cause hyperglycemia and may reduce the glucose-lowering effect of rosiglitazone. Control of diabetes may worsen during steroid courses.
How serious is the interaction between Prednisone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring while on prednisone and adjust antidiabetic therapy as needed. Reduce doses again as the steroid is withdrawn.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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