Drug interactions
Prednisone + Succinylcholine
Severity: Moderate
Prednisone and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with neuromuscular blockers have been linked to acute myopathy, particularly with prolonged use in critically ill patients. Corticosteroids may also modify the duration of neuromuscular blockade.
What this interaction means in plain words
Prednisone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Succinylcholine belongs to Musculoskeletal.
Why it happens
Additive effects on skeletal muscle; the exact mechanism of acute myopathy is not fully established.
What to do
Use the shortest effective duration of both agents and monitor for prolonged weakness. Check creatine kinase if myopathy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Prednisone with Succinylcholine?
MediHelp rates the interaction as moderate. Prednisone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with neuromuscular blockers have been linked to acute myopathy, particularly with prolonged use in critically ill patients. Corticosteroids may also modify the duration of neuromuscular blockade.
How serious is the interaction between Prednisone and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective duration of both agents and monitor for prolonged weakness. Check creatine kinase if myopathy is suspected.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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