Drug interactions
Prednisone + Tazemetostat
Severity: Minor
Prednisone and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate, and prednisone is at most a weak CYP3A4 inducer. Any reduction in tazemetostat exposure is likely small.
What this interaction means in plain words
Prednisone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prednisone belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 induction by prednisone increasing tazemetostat clearance.
What to do
No routine adjustment is required; monitor for reduced tazemetostat efficacy during prolonged high-dose steroid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Prednisone with Tazemetostat?
MediHelp rates the interaction as minor. Prednisone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a CYP3A4 substrate, and prednisone is at most a weak CYP3A4 inducer. Any reduction in tazemetostat exposure is likely small.
How serious is the interaction between Prednisone and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for reduced tazemetostat efficacy during prolonged high-dose steroid therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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