Drug interactions
Prednisone + Tipranavir
Severity: Moderate
Prednisone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir is a complex CYP3A4 and P-gp inhibitor and inducer, and may alter prednisolone exposure. Prednisone could weakly lower protease inhibitor levels, but this is poorly documented.
What this interaction means in plain words
Prednisone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Mixed CYP3A4 and P-gp effects of ritonavir-boosted tipranavir on corticosteroid metabolism; prednisone may weakly induce CYP3A4.
What to do
Monitor for signs of corticosteroid excess and for virologic control during long-term co-therapy, and adjust prednisone dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Prednisone with Tipranavir?
MediHelp rates the interaction as moderate. Prednisone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir is a complex CYP3A4 and P-gp inhibitor and inducer, and may alter prednisolone exposure. Prednisone could weakly lower protease inhibitor levels, but this is poorly documented.
How serious is the interaction between Prednisone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and for virologic control during long-term co-therapy, and adjust prednisone dose as needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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