Drug interactions
Prednisone + Trastuzumab deruxtecan
Severity: Moderate
Prednisone and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can increase the risk of infection through immunosuppression and neutropenia. Corticosteroids also may mask early signs of infection. Interstitial lung disease from trastuzumab deruxtecan is typically treated with corticosteroids.
What this interaction means in plain words
Prednisone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression increasing infection risk.
What to do
Monitor blood counts and watch for fever or infection. Use steroids only as clinically indicated, such as for premedication or interstitial lung disease management.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Prednisone with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Prednisone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can increase the risk of infection through immunosuppression and neutropenia. Corticosteroids also may mask early signs of infection. Interstitial lung disease from trastuzumab deruxtecan is typically treated with corticosteroids.
How serious is the interaction between Prednisone and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for fever or infection. Use steroids only as clinically indicated, such as for premedication or interstitial lung disease management.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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