Drug interactions
Pregabalin + Ramipril
Severity: Moderate
Pregabalin and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips, tongue and throat. Using them together may raise the risk, and airway swelling can be life-threatening.
What this interaction means in plain words
Pregabalin and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Ramipril belongs to Cardiovascular.
Why it happens
Both drugs can independently cause angioedema; ACE inhibitors act via bradykinin accumulation, and the pregabalin mechanism is not established.
What to do
Counsel patients to stop both drugs and seek emergency care if swelling of the face, lips, tongue or throat occurs. Review the need for the combination in patients with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pregabalin and Ramipril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Ramipril?
MediHelp rates the interaction as moderate. Pregabalin and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips, tongue and throat. Using them together may raise the risk, and airway swelling can be life-threatening.
How serious is the interaction between Pregabalin and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop both drugs and seek emergency care if swelling of the face, lips, tongue or throat occurs. Review the need for the combination in patients with prior angioedema.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
