Drug interactions
Pregabalin + Suvorexant
Severity: Moderate
Pregabalin and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin antagonist hypnotic and pregabalin also causes sedation, so together they may increase next-day drowsiness and impair coordination and attention. Significant respiratory depression is not typical of this pair.
What this interaction means in plain words
Pregabalin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective suvorexant dose and monitor for daytime sedation and impaired psychomotor performance. Counsel on driving and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Suvorexant
Frequently asked questions
Can I take Pregabalin with Suvorexant?
MediHelp rates the interaction as moderate. Pregabalin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin antagonist hypnotic and pregabalin also causes sedation, so together they may increase next-day drowsiness and impair coordination and attention. Significant respiratory depression is not typical of this pair.
How serious is the interaction between Pregabalin and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and monitor for daytime sedation and impaired psychomotor performance. Counsel on driving and falls.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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