Drug interactions
Pregabalin + Trandolapril
Severity: Moderate
Pregabalin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with angioedema, so using them together may raise the chance of facial or airway swelling. The risk is uncommon but potentially serious if the airway is involved.
What this interaction means in plain words
Pregabalin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
ACE inhibitors raise bradykinin levels; pregabalin-associated angioedema has an unclear mechanism, and the effects may be additive.
What to do
Warn patients to seek emergency care for swelling of the face, lips, tongue or throat. Stop both drugs and treat if angioedema occurs, avoiding ACE inhibitor rechallenge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Pregabalin with Trandolapril?
MediHelp rates the interaction as moderate. Pregabalin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with angioedema, so using them together may raise the chance of facial or airway swelling. The risk is uncommon but potentially serious if the airway is involved.
How serious is the interaction between Pregabalin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients to seek emergency care for swelling of the face, lips, tongue or throat. Stop both drugs and treat if angioedema occurs, avoiding ACE inhibitor rechallenge.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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