Drug interactions
Pretomanid + Valsartan
Severity: Minor
Pretomanid and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3, a transporter that contributes to hepatic uptake of valsartan. Valsartan exposure could increase, leading to more hypotension or renal effects. Clinical data are limited.
What this interaction means in plain words
Pretomanid and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pretomanid belongs to Anti Bacterial; Valsartan belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure and renal function during pretomanid therapy and lower the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Valsartan?
MediHelp rates the interaction as minor. Pretomanid and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3, a transporter that contributes to hepatic uptake of valsartan. Valsartan exposure could increase, leading to more hypotension or renal effects. Clinical data are limited.
How serious is the interaction between Pretomanid and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during pretomanid therapy and lower the valsartan dose if hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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