Drug interactions
Pretomanid + Vitamin a
Severity: Moderate
Pretomanid and Vitamin a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid regimen is associated with hepatotoxicity, and excess vitamin A can also damage the liver. Combining supplemental high-dose vitamin A may increase liver injury risk.
What this interaction means in plain words
Pretomanid and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pretomanid belongs to Anti Bacterial; Vitamin a belongs to Gastrointestinal Tract.
Why it happens
Additive hepatotoxicity.
What to do
Avoid vitamin A supplements above the recommended daily allowance during therapy. Monitor liver function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin a
- Acitretin + Vitamin a Major
- Etretinate + Vitamin a Major
- Isotretinoin + Vitamin a Major
- Palovarotene + Vitamin a Major
- Bexarotene + Vitamin a Moderate
- Minocycline + Vitamin a Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Vitamin a?
MediHelp rates the interaction as moderate. Pretomanid and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pretomanid regimen is associated with hepatotoxicity, and excess vitamin A can also damage the liver. Combining supplemental high-dose vitamin A may increase liver injury risk.
How serious is the interaction between Pretomanid and Vitamin a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin A supplements above the recommended daily allowance during therapy. Monitor liver function regularly.
What other medicines interact with Vitamin a?
MediHelp also lists interactions of Vitamin a with, for example, Acitretin, Etretinate, Isotretinoin. The full list is on the Vitamin a page.
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