Drug interactions
Primaquine + Solifenacin
Severity: Moderate
Primaquine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use could increase the risk of ventricular arrhythmia. The risk is higher with electrolyte disturbances, bradycardia or structural heart disease.
What this interaction means in plain words
Primaquine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check the baseline ECG and correct potassium and magnesium before starting. Monitor the QTc during the primaquine course in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Primaquine with Solifenacin?
MediHelp rates the interaction as moderate. Primaquine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use could increase the risk of ventricular arrhythmia. The risk is higher with electrolyte disturbances, bradycardia or structural heart disease.
How serious is the interaction between Primaquine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and correct potassium and magnesium before starting. Monitor the QTc during the primaquine course in patients with other risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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