Drug interactions
Primaquine + Tazemetostat
Severity: Minor
Primaquine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may modestly reduce primaquine concentrations. The clinical effect on antimalarial efficacy is uncertain but could matter for radical cure.
What this interaction means in plain words
Primaquine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Primaquine belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tazemetostat increases primaquine clearance.
What to do
No routine dose change is needed. Monitor for treatment failure or relapse of malaria.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Primaquine with Tazemetostat?
MediHelp rates the interaction as minor. Primaquine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may modestly reduce primaquine concentrations. The clinical effect on antimalarial efficacy is uncertain but could matter for radical cure.
How serious is the interaction between Primaquine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for treatment failure or relapse of malaria.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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