Drug interactions
Primaquine + Vorinostat
Severity: Moderate
Primaquine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked with QT prolongation, so combined use may increase the risk of torsades de pointes. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
What this interaction means in plain words
Primaquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically during therapy. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Primaquine with Vorinostat?
MediHelp rates the interaction as moderate. Primaquine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked with QT prolongation, so combined use may increase the risk of torsades de pointes. Patients with cardiac disease or electrolyte abnormalities are at greatest risk.
How serious is the interaction between Primaquine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during therapy. Replace potassium and magnesium as needed.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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