Drug interactions
Primidone + Ruxolitinib
Severity: Moderate
Primidone and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly converted to phenobarbital and induces CYP3A4, which may lower ruxolitinib levels and reduce its efficacy.
What this interaction means in plain words
Primidone and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Primidone and its metabolite phenobarbital induce CYP3A4, increasing ruxolitinib metabolism.
What to do
Monitor clinical response and blood counts, and titrate the ruxolitinib dose accordingly. Consider an alternative non-inducing anticonvulsant where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Ruxolitinib?
MediHelp rates the interaction as moderate. Primidone and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is partly converted to phenobarbital and induces CYP3A4, which may lower ruxolitinib levels and reduce its efficacy.
How serious is the interaction between Primidone and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood counts, and titrate the ruxolitinib dose accordingly. Consider an alternative non-inducing anticonvulsant where possible.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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