Drug interactions
Primidone + Sevoflurane
Severity: Moderate
Primidone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and so adds barbiturate-type CNS depression to sevoflurane. Sedation and respiratory depression may be greater, and chronic enzyme induction may alter drug handling.
What this interaction means in plain words
Primidone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression from primidone and its phenobarbital metabolite.
What to do
Titrate sevoflurane to effect and monitor ventilation and sedation. Continue primidone perioperatively to avoid seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Sevoflurane?
MediHelp rates the interaction as moderate. Primidone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and so adds barbiturate-type CNS depression to sevoflurane. Sedation and respiratory depression may be greater, and chronic enzyme induction may alter drug handling.
How serious is the interaction between Primidone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect and monitor ventilation and sedation. Continue primidone perioperatively to avoid seizures.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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