Drug interactions
Primidone + Temsirolimus
Severity: Moderate
Primidone and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, and its metabolite phenobarbital, induces CYP3A4 and can lower exposure to temsirolimus and its active metabolite sirolimus. This may reduce antitumor efficacy.
What this interaction means in plain words
Primidone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Induction of CYP3A4 increases metabolic clearance of temsirolimus and sirolimus.
What to do
Prefer a non-enzyme-inducing anticonvulsant where possible. If the combination is unavoidable, monitor tumor response and consider a higher temsirolimus dose per labeling guidance for strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Temsirolimus?
MediHelp rates the interaction as moderate. Primidone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, and its metabolite phenobarbital, induces CYP3A4 and can lower exposure to temsirolimus and its active metabolite sirolimus. This may reduce antitumor efficacy.
How serious is the interaction between Primidone and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-enzyme-inducing anticonvulsant where possible. If the combination is unavoidable, monitor tumor response and consider a higher temsirolimus dose per labeling guidance for strong inducers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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