Drug interactions
Procarbazine + Tacrolimus
Severity: Minor
Procarbazine and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is myelosuppressive and immunosuppressive, while topical tacrolimus has low systemic absorption. Additive immunosuppression is unlikely with ointment, but would be significant if systemic tacrolimus were used.
What this interaction means in plain words
Procarbazine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Procarbazine belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Theoretical additive immunosuppression, limited with topical tacrolimus by low systemic exposure.
What to do
Limit the treated area and avoid broken or infected skin. Monitor for skin infection and review the need for topical therapy during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Procarbazine with Tacrolimus?
MediHelp rates the interaction as minor. Procarbazine and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine is myelosuppressive and immunosuppressive, while topical tacrolimus has low systemic absorption. Additive immunosuppression is unlikely with ointment, but would be significant if systemic tacrolimus were used.
How serious is the interaction between Procarbazine and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the treated area and avoid broken or infected skin. Monitor for skin infection and review the need for topical therapy during chemotherapy.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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