Drug interactions
Procarbazine + Trastuzumab deruxtecan
Severity: Moderate
Procarbazine and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause myelosuppression, and trastuzumab deruxtecan is associated with neutropenia. Combined use may increase the risk of severe neutropenia and infection. Combination use is uncommon in practice.
What this interaction means in plain words
Procarbazine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression from the cytotoxic payload of trastuzumab deruxtecan and procarbazine.
What to do
Monitor complete blood counts regularly and watch for fever or infection. Delay or reduce doses according to neutrophil and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Procarbazine with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Procarbazine and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause myelosuppression, and trastuzumab deruxtecan is associated with neutropenia. Combined use may increase the risk of severe neutropenia and infection. Combination use is uncommon in practice.
How serious is the interaction between Procarbazine and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection. Delay or reduce doses according to neutrophil and platelet counts.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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