Drug interactions
Procarbazine + Zolmitriptan
Severity: Contraindicated
Procarbazine and Zolmitriptan: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibitor activity, and MAO-A is the main enzyme that clears zolmitriptan. Combined use raises zolmitriptan exposure and adds serotonergic effects, which can lead to serotonin syndrome and excessive triptan effects.
What this interaction means in plain words
Procarbazine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Zolmitriptan belongs to Central Nervous System.
Why it happens
MAO-A inhibition by procarbazine reduces zolmitriptan metabolism and adds to serotonergic activity.
What to do
Do not give zolmitriptan during procarbazine therapy or within 2 weeks of stopping it. Use a non-MAO-metabolized alternative for migraine and watch for serotonin toxicity if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Procarbazine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has monoamine oxidase inhibitor activity, and MAO-A is the main enzyme that clears zolmitriptan. Combined use raises zolmitriptan exposure and adds serotonergic effects, which can lead to serotonin syndrome and excessive triptan effects.
How serious is the interaction between Procarbazine and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give zolmitriptan during procarbazine therapy or within 2 weeks of stopping it. Use a non-MAO-metabolized alternative for migraine and watch for serotonin toxicity if exposure occurs.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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