Drug interactions
Prochlorperazine + Quinacrine
Severity: Minor
Prochlorperazine and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and could modestly increase prochlorperazine exposure, with greater sedation or extrapyramidal effects. Phenothiazines may also have additive toxicities with quinacrine, but the data are limited.
What this interaction means in plain words
Prochlorperazine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2D6 metabolism of prochlorperazine.
What to do
Monitor for sedation, extrapyramidal symptoms and hypotension, and reduce the prochlorperazine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Quinacrine?
MediHelp rates the interaction as minor. Prochlorperazine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6 and could modestly increase prochlorperazine exposure, with greater sedation or extrapyramidal effects. Phenothiazines may also have additive toxicities with quinacrine, but the data are limited.
How serious is the interaction between Prochlorperazine and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and hypotension, and reduce the prochlorperazine dose if they occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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