Drug interactions
Prochlorperazine + Sage
Severity: Minor
Prochlorperazine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage preparations may cause mild sedation, which could add to prochlorperazine drowsiness. Evidence is minimal and the effect is likely small.
What this interaction means in plain words
Prochlorperazine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; mechanism not firmly established.
What to do
Advise patients to monitor for added drowsiness and avoid driving if affected. No dose change is typically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Sage?
MediHelp rates the interaction as minor. Prochlorperazine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage preparations may cause mild sedation, which could add to prochlorperazine drowsiness. Evidence is minimal and the effect is likely small.
How serious is the interaction between Prochlorperazine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor for added drowsiness and avoid driving if affected. No dose change is typically needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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