Drug interactions
Prochlorperazine + Smoking
Severity: Minor
Prochlorperazine and Smoking: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobacco smoke induces hepatic CYP1A2, which can accelerate the metabolism of some phenothiazines and lower their plasma concentrations. Smokers may therefore need higher doses for the same effect, and stopping smoking can raise levels and cause more sedation or adverse effects.
What this interaction means in plain words
Prochlorperazine and Smoking have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP1A2 (and possibly other enzymes) by polycyclic aromatic hydrocarbons in tobacco smoke increases drug clearance.
What to do
Monitor clinical response and adverse effects when a patient starts or stops smoking, and adjust the prochlorperazine dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Smoking?
MediHelp rates the interaction as minor. Prochlorperazine and Smoking have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tobacco smoke induces hepatic CYP1A2, which can accelerate the metabolism of some phenothiazines and lower their plasma concentrations. Smokers may therefore need higher doses for the same effect, and stopping smoking can raise levels and cause more sedation or adverse effects.
How serious is the interaction between Prochlorperazine and Smoking?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects when a patient starts or stops smoking, and adjust the prochlorperazine dose accordingly.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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