Drug interactions
Prochlorperazine + Sulfamethoxazole
Severity: Moderate
Prochlorperazine and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine can prolong the QT interval, and sulfamethoxazole-containing products have been associated with rare QT prolongation and arrhythmia reports. The added risk is generally small but matters in patients with other QT risk factors.
What this interaction means in plain words
Prochlorperazine and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation; the sulfamethoxazole contribution is weakly established.
What to do
Check baseline ECG and correct potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Prochlorperazine and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine can prolong the QT interval, and sulfamethoxazole-containing products have been associated with rare QT prolongation and arrhythmia reports. The added risk is generally small but matters in patients with other QT risk factors.
How serious is the interaction between Prochlorperazine and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Avoid the combination in congenital long QT syndrome.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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