Drug interactions
Prochlorperazine + Thiothixene
Severity: Moderate
Prochlorperazine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two dopamine-blocking antipsychotics together increase the risk of extrapyramidal symptoms, sedation, QT prolongation and neuroleptic malignant syndrome. The combination gives little added benefit and raises cumulative adverse effect burden.
What this interaction means in plain words
Prochlorperazine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor blockade along with additive sedative and anticholinergic effects.
What to do
Avoid duplicate antipsychotic therapy where possible. If used together, monitor for rigidity, fever, dyskinesia and sedation, and consider an ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Thiothixene?
MediHelp rates the interaction as moderate. Prochlorperazine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two dopamine-blocking antipsychotics together increase the risk of extrapyramidal symptoms, sedation, QT prolongation and neuroleptic malignant syndrome. The combination gives little added benefit and raises cumulative adverse effect burden.
How serious is the interaction between Prochlorperazine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antipsychotic therapy where possible. If used together, monitor for rigidity, fever, dyskinesia and sedation, and consider an ECG.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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