Drug interactions
Prochlorperazine + Tobacco use
Severity: Minor
Prochlorperazine and Tobacco use: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces CYP1A2 and can lower plasma concentrations of some phenothiazines, potentially reducing their effect. When a patient stops smoking, levels may rise and cause more sedation or adverse effects.
What this interaction means in plain words
Prochlorperazine and Tobacco use have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP1A2 by tobacco smoke increases hepatic clearance.
What to do
Review prochlorperazine response and tolerability when smoking status changes, and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Tobacco use?
MediHelp rates the interaction as minor. Prochlorperazine and Tobacco use have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Smoking induces CYP1A2 and can lower plasma concentrations of some phenothiazines, potentially reducing their effect. When a patient stops smoking, levels may rise and cause more sedation or adverse effects.
How serious is the interaction between Prochlorperazine and Tobacco use?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review prochlorperazine response and tolerability when smoking status changes, and adjust the dose as needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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