Drug interactions
Prochlorperazine + Triclofos
Severity: Moderate
Prochlorperazine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with a sedating phenothiazine it can produce excessive drowsiness and CNS depression. Risk is higher in children, older adults and those with respiratory compromise.
What this interaction means in plain words
Prochlorperazine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from trichloroethanol and prochlorperazine.
What to do
Use the lowest effective doses and monitor sedation level and respiration. Avoid additional CNS depressants and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Triclofos?
MediHelp rates the interaction as moderate. Prochlorperazine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with a sedating phenothiazine it can produce excessive drowsiness and CNS depression. Risk is higher in children, older adults and those with respiratory compromise.
How serious is the interaction between Prochlorperazine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation level and respiration. Avoid additional CNS depressants and alcohol.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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