Drug interactions
Prochlorperazine + Trospium chloride
Severity: Moderate
Prochlorperazine and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so together they can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially susceptible to cognitive effects and reduced gastrointestinal motility.
What this interaction means in plain words
Prochlorperazine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects of trospium and prochlorperazine.
What to do
Monitor for anticholinergic toxicity such as retention, constipation and confusion, and consider alternatives in elderly patients. Reduce doses or stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Trospium chloride?
MediHelp rates the interaction as moderate. Prochlorperazine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so together they can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are especially susceptible to cognitive effects and reduced gastrointestinal motility.
How serious is the interaction between Prochlorperazine and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as retention, constipation and confusion, and consider alternatives in elderly patients. Reduce doses or stop one agent if symptoms develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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