Drug interactions
Prochlorperazine + Venlafaxine
Severity: Moderate
Prochlorperazine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and venlafaxine is a weak CYP2D6 inhibitor that may modestly raise prochlorperazine exposure. The combination may increase the risk of arrhythmia and extrapyramidal effects.
What this interaction means in plain words
Prochlorperazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with possible CYP2D6 inhibition by venlafaxine.
What to do
Monitor ECG in patients with cardiac risk factors and correct electrolytes. Watch for extrapyramidal symptoms and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Venlafaxine?
MediHelp rates the interaction as moderate. Prochlorperazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and venlafaxine is a weak CYP2D6 inhibitor that may modestly raise prochlorperazine exposure. The combination may increase the risk of arrhythmia and extrapyramidal effects.
How serious is the interaction between Prochlorperazine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and correct electrolytes. Watch for extrapyramidal symptoms and sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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