Drug interactions
Prochlorperazine + Yohimbe
Severity: Moderate
Prochlorperazine and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that increases sympathetic outflow, causing anxiety, tachycardia and hypertension. A direct reduction of prochlorperazine's effect is not well documented, and the interaction is largely theoretical.
What this interaction means in plain words
Prochlorperazine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic and CNS effects; yohimbine's alpha-2 blockade may counter the sedating and alpha-blocking actions of prochlorperazine, though this is not firmly established.
What to do
Advise against yohimbe use during phenothiazine therapy, and monitor blood pressure, heart rate and psychiatric symptoms if it is taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Yohimbe?
MediHelp rates the interaction as moderate. Prochlorperazine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe contains yohimbine, an alpha-2 antagonist that increases sympathetic outflow, causing anxiety, tachycardia and hypertension. A direct reduction of prochlorperazine's effect is not well documented, and the interaction is largely theoretical.
How serious is the interaction between Prochlorperazine and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against yohimbe use during phenothiazine therapy, and monitor blood pressure, heart rate and psychiatric symptoms if it is taken.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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