Drug interactions
Prochlorperazine + Yohimbine
Severity: Moderate
Prochlorperazine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases sympathetic activity and can cause anxiety, hypertension and tachycardia, while prochlorperazine causes sedation and alpha-1 blockade with hypotension. Their effects oppose each other unpredictably and may reduce the effect of either drug.
What this interaction means in plain words
Prochlorperazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects on adrenergic tone and CNS arousal.
What to do
Monitor blood pressure, heart rate and mental status, and avoid combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Yohimbine?
MediHelp rates the interaction as moderate. Prochlorperazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases sympathetic activity and can cause anxiety, hypertension and tachycardia, while prochlorperazine causes sedation and alpha-1 blockade with hypotension. Their effects oppose each other unpredictably and may reduce the effect of either drug.
How serious is the interaction between Prochlorperazine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status, and avoid combined use where possible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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