Drug interactions
Prochlorperazine + Zotepine
Severity: Moderate
Prochlorperazine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the risk of extrapyramidal symptoms, sedation, QT prolongation and neuroleptic malignant syndrome. Zotepine also lowers the seizure threshold, and the combination offers little benefit over monotherapy.
What this interaction means in plain words
Prochlorperazine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor blockade with additive sedation and QT effects.
What to do
Avoid concurrent antipsychotics where possible. If necessary, monitor for rigidity, fever, seizures and dyskinesia, and check an ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Zotepine?
MediHelp rates the interaction as moderate. Prochlorperazine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the risk of extrapyramidal symptoms, sedation, QT prolongation and neuroleptic malignant syndrome. Zotepine also lowers the seizure threshold, and the combination offers little benefit over monotherapy.
How serious is the interaction between Prochlorperazine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent antipsychotics where possible. If necessary, monitor for rigidity, fever, seizures and dyskinesia, and check an ECG.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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