Drug interactions
Progesterone + Rifaximin
Severity: Minor
Progesterone and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifaximin is minimally absorbed and a P-glycoprotein substrate, and progesterone may inhibit P-gp in vitro. Systemic rifaximin exposure is very low, so a clinically relevant interaction is unlikely except in severe hepatic impairment.
What this interaction means in plain words
Progesterone and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Progesterone belongs to Endocrine; Rifaximin belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by progesterone could slightly increase rifaximin absorption.
What to do
No dose adjustment is needed; be aware of the theoretical effect in patients with severe liver impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
- Dronedarone + Rifaximin Moderate
Frequently asked questions
Can I take Progesterone with Rifaximin?
MediHelp rates the interaction as minor. Progesterone and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifaximin is minimally absorbed and a P-glycoprotein substrate, and progesterone may inhibit P-gp in vitro. Systemic rifaximin exposure is very low, so a clinically relevant interaction is unlikely except in severe hepatic impairment.
How serious is the interaction between Progesterone and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of the theoretical effect in patients with severe liver impairment.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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