Drug interactions
Progesterone + Saquinavir
Severity: Moderate
Progesterone and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually boosted with ritonavir, inhibits CYP3A4 and may increase progesterone levels. Progestogen-related adverse effects may become more pronounced.
What this interaction means in plain words
Progesterone and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Saquinavir (with ritonavir boosting) inhibits CYP3A4 metabolism of progesterone.
What to do
Monitor for sedation, dizziness, fluid retention and bleeding changes, and lower the progesterone dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Frequently asked questions
Can I take Progesterone with Saquinavir?
MediHelp rates the interaction as moderate. Progesterone and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually boosted with ritonavir, inhibits CYP3A4 and may increase progesterone levels. Progestogen-related adverse effects may become more pronounced.
How serious is the interaction between Progesterone and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness, fluid retention and bleeding changes, and lower the progesterone dose if adverse effects develop.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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