Drug interactions
Propafenone + Rimegepant
Severity: Moderate
Propafenone and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a P-glycoprotein substrate, and propafenone's inhibition of this transporter may modestly increase rimegepant exposure. The expected effect is small, and rimegepant has a good tolerability profile.
What this interaction means in plain words
Propafenone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Rimegepant belongs to Central Nervous System.
Why it happens
P-glycoprotein inhibition by propafenone reduces rimegepant efflux and raises its exposure.
What to do
Avoid taking a second rimegepant dose within 48 hours when the patient is taking a P-gp inhibitor, as the labeling advises. Monitor for adverse effects such as nausea and hypersensitivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Propafenone with Rimegepant?
MediHelp rates the interaction as moderate. Propafenone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimegepant is a P-glycoprotein substrate, and propafenone's inhibition of this transporter may modestly increase rimegepant exposure. The expected effect is small, and rimegepant has a good tolerability profile.
How serious is the interaction between Propafenone and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours when the patient is taking a P-gp inhibitor, as the labeling advises. Monitor for adverse effects such as nausea and hypersensitivity.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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