Drug interactions
Propafenone + Solifenacin
Severity: Moderate
Propafenone and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone can prolong QRS and QT intervals and is proarrhythmic, and solifenacin may add a small QT effect. Propafenone is also metabolised by CYP2D6 and CYP3A4, which solifenacin does not meaningfully affect.
What this interaction means in plain words
Propafenone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor the ECG during co-administration and correct electrolytes. Consider an alternative bladder agent in patients with structural heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Solifenacin?
MediHelp rates the interaction as moderate. Propafenone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone can prolong QRS and QT intervals and is proarrhythmic, and solifenacin may add a small QT effect. Propafenone is also metabolised by CYP2D6 and CYP3A4, which solifenacin does not meaningfully affect.
How serious is the interaction between Propafenone and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG during co-administration and correct electrolytes. Consider an alternative bladder agent in patients with structural heart disease.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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