Drug interactions
Propafenone + Vemurafenib
Severity: Major
Propafenone and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can cause concentration-dependent QT prolongation and propafenone has proarrhythmic effects. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Propafenone and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propafenone belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation and proarrhythmic effects.
What to do
Avoid the combination where possible. If both are needed, monitor ECG and electrolytes at baseline and periodically, and interrupt or reduce vemurafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Propafenone with Vemurafenib?
MediHelp rates the interaction as major. Propafenone and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can cause concentration-dependent QT prolongation and propafenone has proarrhythmic effects. The combination raises the risk of torsades de pointes.
How serious is the interaction between Propafenone and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor ECG and electrolytes at baseline and periodically, and interrupt or reduce vemurafenib if QTc becomes markedly prolonged.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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