Drug interactions
Propofol + Protriptyline
Severity: Moderate
Propofol and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that may add to propofol's CNS depression and hypotension. Anticholinergic effects and arrhythmia risk may also be relevant perioperatively.
What this interaction means in plain words
Propofol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and cardiovascular effects from tricyclic receptor blockade combined with propofol.
What to do
Titrate propofol cautiously and monitor ECG, blood pressure and sedation depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Protriptyline?
MediHelp rates the interaction as moderate. Propofol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that may add to propofol's CNS depression and hypotension. Anticholinergic effects and arrhythmia risk may also be relevant perioperatively.
How serious is the interaction between Propofol and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor ECG, blood pressure and sedation depth.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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