Drug interactions
Propofol + Quazepam
Severity: Moderate
Propofol and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine and adds to the sedative and respiratory depressant effects of propofol. Hypoventilation, hypotension and prolonged sedation may occur.
What this interaction means in plain words
Propofol and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs potentiate GABA-A receptor mediated inhibition, producing additive CNS and respiratory depression.
What to do
Reduce the propofol dose and titrate to effect while monitoring respiration, oxygen saturation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Quazepam?
MediHelp rates the interaction as moderate. Propofol and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine and adds to the sedative and respiratory depressant effects of propofol. Hypoventilation, hypotension and prolonged sedation may occur.
How serious is the interaction between Propofol and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the propofol dose and titrate to effect while monitoring respiration, oxygen saturation and blood pressure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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