Drug interactions
Propofol + Rifampin
Severity: Minor
Propofol and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic enzymes and may increase propofol clearance, so higher doses may be needed for the same effect. The effect is modest and propofol is titrated to response.
What this interaction means in plain words
Propofol and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induction of CYP2B6 and glucuronidation increases propofol metabolism.
What to do
Titrate propofol to clinical effect and expect possible higher dose requirements in patients on rifampin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Rifampin?
MediHelp rates the interaction as minor. Propofol and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin induces hepatic enzymes and may increase propofol clearance, so higher doses may be needed for the same effect. The effect is modest and propofol is titrated to response.
How serious is the interaction between Propofol and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to clinical effect and expect possible higher dose requirements in patients on rifampin.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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