Drug interactions
Propofol + Thiothixene
Severity: Moderate
Propofol and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic and adds to the CNS depressant and hypotensive effects of propofol. Patients may need less propofol and may recover more slowly.
What this interaction means in plain words
Propofol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-adrenergic and histamine blockade by thiothixene combined with propofol vasodilation.
What to do
Titrate propofol cautiously with reduced doses, and monitor sedation depth and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Thiothixene?
MediHelp rates the interaction as moderate. Propofol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic and adds to the CNS depressant and hypotensive effects of propofol. Patients may need less propofol and may recover more slowly.
How serious is the interaction between Propofol and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously with reduced doses, and monitor sedation depth and blood pressure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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