Drug interactions
Propofol + Triazolam
Severity: Moderate
Propofol and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a potent hypnotic benzodiazepine, and with propofol it increases sedation and the risk of respiratory depression and hypotension. Anesthetic requirements are usually lower.
What this interaction means in plain words
Propofol and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Reduce propofol dose and titrate to effect. Monitor oxygen saturation, ventilation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Triazolam?
MediHelp rates the interaction as moderate. Propofol and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a potent hypnotic benzodiazepine, and with propofol it increases sedation and the risk of respiratory depression and hypotension. Anesthetic requirements are usually lower.
How serious is the interaction between Propofol and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dose and titrate to effect. Monitor oxygen saturation, ventilation and blood pressure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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