Drug interactions
Propofol + Triclofos
Severity: Moderate
Propofol and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with propofol it causes additive sedation. Deeper than intended CNS and respiratory depression may occur.
What this interaction means in plain words
Propofol and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation by trichloroethanol and propofol.
What to do
Lower propofol doses and titrate carefully while monitoring sedation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Triclofos?
MediHelp rates the interaction as moderate. Propofol and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug of trichloroethanol, and with propofol it causes additive sedation. Deeper than intended CNS and respiratory depression may occur.
How serious is the interaction between Propofol and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower propofol doses and titrate carefully while monitoring sedation and respiration.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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