Drug interactions
Propofol + Trifluoperazine
Severity: Moderate
Propofol and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine can add to propofol sedation and hypotension, and both drugs can affect seizure threshold and QT in different ways. Recovery from anesthesia may be prolonged.
What this interaction means in plain words
Propofol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-adrenergic blockade.
What to do
Titrate propofol to effect with reduced doses, and monitor blood pressure and sedation level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Trifluoperazine?
MediHelp rates the interaction as moderate. Propofol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine can add to propofol sedation and hypotension, and both drugs can affect seizure threshold and QT in different ways. Recovery from anesthesia may be prolonged.
How serious is the interaction between Propofol and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with reduced doses, and monitor blood pressure and sedation level.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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