Drug interactions
Propofol + Triprolidine
Severity: Moderate
Propofol and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine may enhance the sedative and hypnotic effect of propofol, leading to deeper sedation or a lower dose requirement. Hypotension and respiratory depression may be more pronounced.
What this interaction means in plain words
Propofol and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and GABA-A potentiation.
What to do
Titrate propofol to effect with continuous monitoring of airway, ventilation and blood pressure. Tell the anesthesia team about recent antihistamine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Triprolidine?
MediHelp rates the interaction as moderate. Propofol and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine may enhance the sedative and hypnotic effect of propofol, leading to deeper sedation or a lower dose requirement. Hypotension and respiratory depression may be more pronounced.
How serious is the interaction between Propofol and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous monitoring of airway, ventilation and blood pressure. Tell the anesthesia team about recent antihistamine use.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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