Drug interactions
Propranolol + Ropivacaine
Severity: Moderate
Propranolol and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropivacaine can cause hypotension and bradycardia, especially with epidural or high-dose regional use, and propranolol may add to these effects. Reduced hepatic blood flow from beta-blockade may also modestly lower local anesthetic clearance.
What this interaction means in plain words
Propranolol and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression, with possibly reduced hepatic clearance of the anesthetic.
What to do
Monitor blood pressure and heart rate during neuraxial or regional blocks and use the lowest effective ropivacaine dose. Treat bradycardia and hypotension promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Frequently asked questions
Can I take Propranolol with Ropivacaine?
MediHelp rates the interaction as moderate. Propranolol and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropivacaine can cause hypotension and bradycardia, especially with epidural or high-dose regional use, and propranolol may add to these effects. Reduced hepatic blood flow from beta-blockade may also modestly lower local anesthetic clearance.
How serious is the interaction between Propranolol and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during neuraxial or regional blocks and use the lowest effective ropivacaine dose. Treat bradycardia and hypotension promptly.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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