Drug interactions
Propranolol + Sevoflurane
Severity: Moderate
Propranolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics like sevoflurane cause vasodilation and myocardial depression, and propranolol limits compensatory responses. This increases the risk of intraoperative hypotension and bradycardia.
What this interaction means in plain words
Propranolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive negative inotropic and vasodilatory effects with blunted sympathetic compensation.
What to do
Continue beta-blockers perioperatively where indicated and monitor hemodynamics closely. Adjust the anesthetic depth and have agents available to treat hypotension and bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Propranolol with Sevoflurane?
MediHelp rates the interaction as moderate. Propranolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics like sevoflurane cause vasodilation and myocardial depression, and propranolol limits compensatory responses. This increases the risk of intraoperative hypotension and bradycardia.
How serious is the interaction between Propranolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue beta-blockers perioperatively where indicated and monitor hemodynamics closely. Adjust the anesthetic depth and have agents available to treat hypotension and bradycardia.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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